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KMID : 1145120170150030345
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Asian Journal of Beauty and Cosmetology
2017 Volume.15 No. 3 p.345 ~ p.353
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Preparation of Self Microemulsion of Ferulic Acid
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Zuo Jin-Hui
Li Qiang
Dong Ze-Yuan
Meng Hong
Li Li
Dong Yin-Mao
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Abstract
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Purpose: The optimum formulation and preparation process of ferulic acid self microemulsion was studied.
Methods: The effect of different surfactants on the formation of microemulsion area was studied by pseudo three phase diagram method. To determine the best ratio among surfactants, cosurfactant and oil phase, the uniformity and particle size of microemulsion was evaluated by nanoparticle size analyzer. Finally, the stability of microemulsion was measured by nanoparticle size analyzer and zeta potential analyzer.
Results: Combined the results of pseudo three phase diagram with particle size distribution, the best ratio of self microemulsion:polyoxyethylene castor oil (Cremophor EL): polyethylene glycol 40 (PEG 40):Ethanol:isopropyl myristate (IPM) is about 3.15:3.15:1.8:1. The average particle size of microemulsion is about 15.5 nm which of system contains about 90% water. The maximum drug loading of ferulic acid was 5.2%, and this self microemulsion formulation has good stability.
Conclusion: The formula greatly improves the solubility of insoluble materials like ferulic acid in water and it has guiding significance for the application of the microemulsion in practical production.
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KEYWORD
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Whitening, Ferulic acid, Formulation process, Microemulsion, Drug loading
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